In Los Angeles, the police put a residential building in quarantine. Meanwhile, the flight attendants of Trans Sky Air, Jenny and Paula, are welcoming the passengers of flight TS Air 318 from Los Angeles to Kansas City with Captain Forrest and Co-Pilot Wilsy. Teacher Henry brings a cage of hamsters to the cabin, but Jenny tells him that it should be transported in the cargo hold. However, one hamster bites the fingertip of the fat passenger Ralph. Soon, Ralph vomits and becomes aggressive, attacking Paula. The male passengers help Jenny and lock Ralph in the bathroom while Captain Forrest requests an emergency landing. When they land in the airport, they find all the gates closed and the Captain heads the plane to an abandoned terminal. Employee Ed helps the crew and passengers to reach the exit, but they find that they are closed. Soon they discover that the place is in quarantine and there is no way out.

Three stories told simultaneous in ninety minutes of real time: a Republican Senator who's a presidential hopeful gives an hour-long interview to a skeptical television reporter, detailing a strategy for victory in Afghanistan; two special forces ambushed on an Afghani ridge await rescue as Taliban forces close in; a poli-sci professor at a California college invites a promising student to re-engage. Decisions press upon the reporter, the student, and the soldiers.

Lambeau Fields lives a middle-class lifestyle in America along with his wife, Barb, and a gorgeous daughter, Michelle, who he has brought up as a son. Lambeau is a failure and has virtually given up on his career as a football coach. Then his friend, Freddie Wiseman, encourages him to re-enter this field, and he does so by re-locating to Plainfolk in Texas and joins the Heartland State University. It is here he will meet some of the most pathetic players, and quite disillusioned he goes about to find new-comers. He finds a kicker in Jasminder Featherfoot, provided of course, he keeps her involvement secret from the rest of her family. Then he finds Lance Truman, whose drag queen dad has brought him up more like a tom-girl. With these additions and others Lambeau sets forth to include his team in the next Super...Er...Toilet Bowl 2 series, and it is here that he will find that Lance fumbles...